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Science 18 August 1967:
Vol. 157. no. 3790, pp. 827 - 829
DOI: 10.1126/science.157.3790.827
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Articles

Blood Viscosity: Influence of Erythrocyte Deformation

Shu Chien 1, Shunichi Usami 1, Robert J. Dellenback 1, and Magnus I. Gregersen 1

1 Laboratory of Hemorheology and Department of Physiology, Columbia University College of Physicians and Surgeons, New York, New York

Suspensions of canine and human erythocytes hardened with acetaldehyde differ from the suspensions of normal erythrocytes with respect to their rheological behavior. Normal erythrocytes can be packed by centrifugation so that the sediment volume is nearly 100 percent cells, but the hardened erythrocytes (RBC's) can be packed only to approximately 60 percent cells. At the same cell percentage the viscosity of the hardened RBC suspension is higher than that of the suspension of normal erythocytes. An increase in shear stress deforms the normal erythocytes and lowers the suspension viscosity, but has no influence on the viscosity of the hardened cell suspension. In blood with high cell percentages, the shear deformation of normal RBC's plays an important role in reducing viscosity and facilitating flow at high shear stresses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Rheological Aspects of Sickle Cell Disease.
P. P. Klug, L. S. Lessin, and P. Radice (1974)
Arch Intern Med 133, 577-590
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Shear Dependence of Effective Cell Volume as a Determinant of Blood Viscosity.
S. Chien (1970)
Science 168, 977-979
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Fluid Drop-Like Transition of Erythrocytes under Shear.
H. Schmid-Schonbein and R. Wells (1969)
Science 165, 288-291
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Flow Characteristics of Human Erythrocytes through Polycarbonate Sieves.
M. I. Gregersen, C. A. Bryant, W. E. Hammerle, S. Usami, and S. Chien (1967)
Science 157, 825-827
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Blood Viscosity: Influence of Erythrocyte Aggregation.
S. Chien, S. Usami, R. J. Dellenback, M. I. Gregersen, L. B. Nanninga, and M. M. Guest (1967)
Science 157, 829-831
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