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Science 18 August 1967:
Vol. 157. no. 3790, pp. 821 - 822
DOI: 10.1126/science.157.3790.821
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Articles

Deoxycytidylate and Deoxyguanylate Kinase Activity in Pneumococci after Exposure to Known Polyribonucleotides

William Firshein 1, Ruth C. Benson 1, and Margaret Sease 1

1 Department of Biology, Wesleyan University, Middletown, Connecticut

Polycytidylic acid and to a lesser extent polyadenylic acid enhance the activity of deoxycytidylate and deoxyguanylate kinases in resting cell suspensions of encapsulated pneumococci. The active intracellular materials appear to be oligomers of A and C, respectively. The stimulation of the kinase activities is amino-acid dependent and can be abolished by the addition of chloramphenicol. The addition of all eight naturally occurring deoxyribonucleosides and deoxyribonucleotides to cell suspensions containing the homopolymers leads to a selective enhancement of DNA synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Release of Nuclear DNA Template Restrictions by Specific Polyribonucleotides.
D. G. Brown and D. S. Coffey (1971)
Science 171, 176-178
   Abstract »    PDF »
Antibody Formation: Stimulation by Polyadenylic and Polycytidylic Acids.
W. Braun and M. Nakano (1967)
Science 157, 819-821
   Abstract »    PDF »


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