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Science 18 August 1967:
Vol. 157. no. 3790, pp. 819 - 821
DOI: 10.1126/science.157.3790.819
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Articles

Antibody Formation: Stimulation by Polyadenylic and Polycytidylic Acids

Werner Braun 1 and Masayasu Nakano 1

1 Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey

Complexes of polyadenylic and polyuridylic acids, or of polycytidylic acid and methylated bovine serum albumin, enhance the early rate of increase in numbers of antibody-forming spleen cells in mice immunized with sheep red blood cells or other particulate antigens. Polyadenylic and polycytidylic acids, respectively, appear to be the source of the critical stimulators which, as demonstrated by others in bacteria, may act by influencing nucleotide kinase activity. The stimulated antibody response, but not the normal response, is antagonized by kinetin riboside and by an adenosine derivative occurring in sRNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Studies on Hypoxia: XII. Detrimental Effects of Synthetic Polyribonucleotides on Epiphyseal Plates of Rats Exposed to Hypoxia.
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Reduced incidence of spontaneous mammary tumors in C3H/He mice after treatment with polyadenylate-polyuridylate.
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Viral Infection and Host Defense.
W. A. Carter and E. De Clercq (1974)
Science 186, 1172-1178
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Interferon and Interferon Inducers in the Treatment of Malignancies.
H. B. Levy (1970)
Arch Intern Med 126, 78-83
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Induction of Interferon by Nonviral Agents.
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Arch Intern Med 126, 94-108
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Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections.
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Cornea and Sclera.
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Arch Ophthalmol 83, 637-657
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Deoxycytidylate and Deoxyguanylate Kinase Activity in Pneumococci after Exposure to Known Polyribonucleotides.
W. Firshein, R. C. Benson, and M. Sease (1967)
Science 157, 821-822
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Science. ISSN 0036-8075 (print), 1095-9203 (online)