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Science 4 August 1967:
Vol. 157. no. 3788, pp. 561 - 563
DOI: 10.1126/science.157.3788.561
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Articles

Addiction Liability of Albino Rats: Breeding for Quantitative Differences in Morphine Drinking

John R. Nichols 1 and Sigmund Hsiao 1

1 Department of Psychology, Southeastern Louisiana College, Hammond 70401

Selective breeding produced two strains of rats that differ in their susceptibility to morphine addiction. Inbreeding the more susceptible rats in an unselected population produced susceptible offspring; inbreeding resistant rats produced resistant offspring. Further selection and inbreeding increased the strain difference in the F2 and F3 generations. The F3 generation also differed in their susceptibility to alcohol addiction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Convulsions and Hallucinatory Behavior.
C. F. Essig and R. C. Lam (1968)
Arch Neurol 18, 626-632
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Science. ISSN 0036-8075 (print), 1095-9203 (online)