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Science 28 July 1967:
Vol. 157. no. 3787, pp. 454 - 455
DOI: 10.1126/science.157.3787.454
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Articles

Deficient Complement Fixation by Aggregated Gamma Globulin from Hypogammaglobulinemic Patients

Richard J. Pickering 1, Richard Hong 1, and Robert A. Good 1

1 Pediatric Research Laboratories, Variety Club Heart Hospital, University of Minnesota, Minneapolis 55455

We found that several normal samples of aggregated gamma globulin consistently fixed essentially equal amounts of guinea pig complement, while samples of gamma globulin from three of four hypogammaglobulinemic patients were markedly deficient in this biologic function. Thus, the previously observed limited heterogeneity of gamma globulin in patients with hypogammaglobulinemia is also associated with inefficiency in at least one biological function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lupus Nephritis: Varying Complement-Fixing Properties of Immuvnoglobulin G Antibodies to Antigens of Cel Nuclei.
T. Tojo and G. J. Friou (1968)
Science 161, 904-906
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