Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 July 1967:
Vol. 157. no. 3787, pp. 432 - 434
DOI: 10.1126/science.157.3787.432
Prev | Table of Contents | Next

Articles

Aminoaciduria Resulting from Cycloleucine Administration in Man

R. R. Brown 1

1 Division of Clinical Oncology, University of Wisconsin Medical School, Madison 53706

Cycloleucine (1-aminocyclopentanecarboxylic acid) administration in cancer patients resulted in a reversible marked aminoaciduria consisting predominantly of cystine, ornithine, lysine, and arginine, with only minor elevations of other amino acids. Plasma levels of amino acids were essentially unchanged except for slight decreases in ornithine and lysine. This aminoaciduria is most likely due to a blockage by the drug of the renal tubular reabsorption of cystine, ornithine, lysine, and arginine, resulting in an aminoaciduria of the type seen in cystinuria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Blood and Urine Amino Acid Aberrations: Physiologic and Pathological Changes in Patients Without Inborn Errors of Amino Acid Metabolism.
R. D. Feigin (1969)
Arch Pediatr Adolesc Med 117, 24-47
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)