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Science 21 July 1967:
Vol. 157. no. 3786, pp. 322 - 323
DOI: 10.1126/science.157.3786.322
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Articles

Delayed Hypersensitivity: Bone Marrow as the Source of Cells in Delayed Skin Reactions

David M. Lubaroff 1 and Byron H. Waksman 1

1 Department of Microbiology, Yale University, New Haven, Connecticut

Adult Lewis rats were thymectomized, irradiated, and restored with bone marrow from allogeneic (or F1) donors. They were passively sensitized to tuberculin by a subsequent transfer of Lewis lymph node cells and were given intradermal skin tests with tuberculoprotein. In 24-hour skin reactions the majority of cells, in successive experiments, were shown to be allogeneic (or F1) with the use of isoantibody against the antigens of the transplanted marrow cells and by the indirect fluorescent antibody technique. Our results demonstrate that the non-specific cells making up a large proportion of the infiltrating elements in tuberculin skin reactions probably originate in the bone marrow.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In vitro Lymphocyte Reactivity during Depression of Tuberculin Hypersensitivity by 6-Mercaptopurine.
B. Zweiman and S. M. Phillips (1970)
Science 169, 284-285
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Bone Marrow and Spleen: Dissociation of Immunologic Properties by Cortisone.
M. A. Levine and H. N. Claman (1970)
Science 167, 1515-1517
   Abstract »    PDF »
Toxic Epidermal Necrolysis and Homologous Disease in Hamsters.
R. E. Billingham and J. W. Streilein (1968)
Arch Dermatol 98, 528-539
   Abstract »    PDF »


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