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Science 21 July 1967:
Vol. 157. no. 3786, pp. 267 - 273
DOI: 10.1126/science.157.3786.267
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Articles

Antibody Variability

Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability

O. Smithies 1

1 University of Wisconsin, Madison

I have analyzed the available amino acid sequence data from 30 myelomatosis-derived proteins. Several types of variation are apparent. I conclude that a major and genetically predetermined contribution to the variability of these proteins and of antibodies could be provided by chromosomal rearrangements resulting from somatic recombination between similar but not identical genes in antibody gene pairs. My hypothesis suggests many new types of experiment and can be tested (31).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Templated, Targeted Sequence Diversification Displays a Similar Choreography in Different Organisms.
V. David and N. Maizels (1989)
Cold Spring Harb Symp Quant Biol 54, 227-231
   Abstract »    PDF »
From antibody structure to immunological diversification of immune response.
C Milstein (1986)
Science 231, 1261-1268
   PDF »
Antibody diversity.
J. Seidman, A Leder, M Nau, B Norman, and P Leder (1978)
Science 202, 11-17
   Abstract »    PDF »
Mechanism of Antibody Diversity: Germ Line Basis for Variability.
L. Hood and D. W. Talmage (1970)
Science 168, 325-334
   PDF »
Immunoglobulin Structure: Variability and Homology.
F. W. Putnam (1969)
Science 163, 633-643
   PDF »
The Genetic Basis of Antibody Variability.
O. Smithies (1967)
Cold Spring Harb Symp Quant Biol 32, 161-168
   Abstract »    PDF »
Summary: Waiting for the End.
N. Kaj Jerne (1967)
Cold Spring Harb Symp Quant Biol 32, 591-603
   Abstract »    PDF »


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