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Science 14 July 1967:
Vol. 157. no. 3785, pp. 196 - 198
DOI: 10.1126/science.157.3785.196
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Articles

Transport of Protein by Goldfish Optic Nerve Fibers

Bernice Grafstein 1

1 Rockefeller University, New York

After tritiated leucine was injected into the eye of goldfish, radio-active protein synthesized by the ganglion cell bodies moved down the optic axons at an average rate of 0.4 mm per day. Radioautograms of the optic tectum in which these axons end show that, as early as 24 hours after the injection, before the radioactivity in the tectal layer containing the optic axons had risen above background level, the layer containing the axon terminals was already heavily labeled. The radioactivity in the terminals reached a maximum about 48 hours after the injection and remained approximately constant for at least 23 days thereafter, whereas the radioactivity in the fiber layer increased significantly during the same interval, as the slowly moving protein component entered it. Thus there appears to be a special mechanism for rapid transport of protein from the cell body to the synaptic terminals, as well as a slower movement of protein down the axon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Axonal Transport of Gangliosides in the Goldfish Optic Nerve.
D. S. Forman and R. W. Ledeen (1972)
Science 177, 630-633
   Abstract »    PDF »
Radioautography of the Optic Tectum of the Goldfish after Intraocular Injection of [3H]Proline.
J. H. Neale, E. A. Neale, and B. W. Agranoff (1972)
Science 176, 407-410
   Abstract »    PDF »
Synaptic Transmission Depressed by Colchicine Blockade of Axoplasmic Flow.
M. PerisacuteIcacute and M. Cuenod (1972)
Science 175, 1140-1142
   Abstract »    PDF »
Transneuronal Transfer of Radioactivity in the Central Nervous System.
B. Grafstein (1971)
Science 172, 177-179
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)