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Science 7 July 1967:
Vol. 157. no. 3784, pp. 96 - 97
DOI: 10.1126/science.157.3784.96
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Articles

Pemoline and Magnesium Hydroxide: Lack of Effect on RNA and Protein Synthesis

Herman H. Stein 1 and Tobias O. Yellin 1

1 Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois 60064

Brain RNA polymerase isolated from rats treated with pemoline and magnesium hydroxide (Cylert) was not more active than enzyme from control animals. The drug did not increase enzymic activity in vitro. Pemoline did not significantly affect either RNA or protein synthesis in suspensions of Ehrlich ascites carcinoma cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)