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Science 30 June 1967:
Vol. 156. no. 3783, pp. 1755 - 1757
DOI: 10.1126/science.156.3783.1755
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Articles

Light Chains of Rabbit Immunoglobulin: Assignment to the Kappa Class

Russell F. Doolittle 1 and Kenneth H. Astrin 1

1 Departments of Chemistry and Biology, University of California. San Diego, La Jolla

Normal rabbit gamma globulin was reduced under conditions presumed to break only interchain disulfide bridges, and the reduiced product was then blocked with C14-iodoacetamide. The light chains were separated from the heavy chains and subjected to peptic digestion. Two radioactive peptides were recovered from the digest. The peptides are apparently overlapping and represent the carboxyterminuis. Comparison of this region in the rabbit light chains with the corresponding amino acid sequences in various mouse and human light chains indicates that the rabbit light chains are of the K-class.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibody Variability: Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability.
O. Smithies (1967)
Science 157, 267-273
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On the Structure of Antibody Active Sites.
S. J. Singer, L. I. Slobin, N. O. Thorpe, and J. W. Fenton II (1967)
Cold Spring Harb Symp Quant Biol 32, 99-110
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Science. ISSN 0036-8075 (print), 1095-9203 (online)