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Science 30 June 1967:
Vol. 156. no. 3783, pp. 1748 - 1750
DOI: 10.1126/science.156.3783.1748
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Articles

Cholinesterase in Plasma: First Reported Absence in the Bantu; Half-life Determination

Trefor Jenkins 1, Doris Balinsky 1, and D. W. Patient 2

1 South African Institute for Medical Research, Johannesburg, Transvaal
2 Jane Furse Memorial Hospital, Sekhuniland, Transvaal

A Bantu schoolgirl is the first non-Caucasoid found homozygous for the "silent" cholinesterase gene. Investigation of her family revealed two heterozygotes. The propositus possesses no antibody to normal cholinesterase. Transfused cholinesterase had in her a half-life of approximately 10 days.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Albumin, a New Biomarker of Organophosphorus Toxicant Exposure, Identified by Mass Spectrometry.
E. S. Peeples, L. M. Schopfer, E. G. Duysen, R. Spaulding, T. Voelker, C. M. Thompson, and O. Lockridge (2005)
Toxicol. Sci. 83, 303-312
   Abstract »    Full Text »    PDF »
The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning.
M. Guven, M. Sungur, and B. Eser (2004)
Human and Experimental Toxicology 23, 365-368
   Abstract »    PDF »
Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model.
Y. Ashani and S. Pistinner (2004)
Toxicol. Sci. 77, 358-367
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)