Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 June 1967:
Vol. 156. no. 3783, pp. 1738 - 1739
DOI: 10.1126/science.156.3783.1738
Prev | Table of Contents | Next

Articles

Dimethyl Sulfoxide Protects Tightly Coupled Mitochondria from Freezing Damage

David B. Dickinson 1, M. Joan Misch 1, and Robert E. Drury 1

1 Department of Horticulture, University of Illinois, Urbana 61801

Dimethyl sulfoxide prevented loss of respiratory control and decrease in efficiency of oxidative phosphorylation when plant mitochondria were stored in liquid nitrogen. Respiration was severely inhibited and was not stimulated by adenosine diphosphate when mitochondria were frozen in liquid nitrogen without dimethyl sulfoxide. Thus, isolated mitochondria provide a model system for the study of the effects of freezing on biological membranes and of the prevention, by dimethyl sulfoxide, of freezing damage.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glucose 6-Phosphate Release of Wild-type and Mutant Human Brain Hexokinases from Mitochondria.
D. A. Skaff, C. S. Kim, H. J. Tsai, R. B. Honzatko, and H. J. Fromm (2005)
J. Biol. Chem. 280, 38403-38409
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)