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Science 23 June 1967:
Vol. 156. no. 3782, pp. 1602 - 1603
DOI: 10.1126/science.156.3782.1602
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Articles

L-Asparaginase: Inhibition of Early Mitosis in Regenerating Rat Liver

F. F. Becker 1 and J. D. Broome 1

1 Department of Pathology, New York University School of Medicine, New York

L-Asparaginase in agouti serum and in extracts from Escherichia coli inhibits the early wave of mitosis occurring in rat liver approximately 30 hours after hepatectomy, but even with continued treatment of the animal the later wave at 50 hours is not inhibited. This result differs from the permanent inhibition of growth which asparaginase causes in various tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell Growth Stimulation by CRASH, an Asparaginase-like Protein Overexpressed in Human Tumors and Metastatic Breast Cancers.
U. H. WEIDLE, V. EVTIMOVA, S. ALBERTI, E. GUERRA, N. FERSIS, and S. KAUL (2009)
Anticancer Res 29, 951-963
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Science. ISSN 0036-8075 (print), 1095-9203 (online)