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Science 23 June 1967:
Vol. 156. no. 3782, pp. 1597 - 1599
DOI: 10.1126/science.156.3782.1597
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Articles

Ionic Mechanisms of Cholinergic Excitation in Molluscan Neurons

D. J. Chiarandini 1, E. Stefani 1, and H. M. Gerschenfeld 1

1 Instituto de Anatomiacgra General ggr Embryologiacgra, Facultad de Ciencias Médicas, Buenos Aires, Argentina

Acetylcholine appears to be an excitatory transmitter at synapses on two different types of molluscan nerve cells: the so-called D- and CILDA neurons. The action of this substance is different in the two cases. In D-neurons, this compound increases the permeability of the subsynaptic or somatic membrane to chloride ions, and through a net efflux of this anion, depolarizes the cell. In CILDA neurons, on the other hand, acetylcholine depolarzies the cell by increasing its permeability to sodium ions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification and Functional Expression of a Family of Nicotinic Acetylcholine Receptor Subunits in the Central Nervous System of the Mollusc Lymnaea stagnalis.
P. van Nierop, S. Bertrand, D. W. Munno, Y. Gouwenberg, J. van Minnen, J. D. Spafford, N. I. Syed, D. Bertrand, and A. B. Smit (2006)
J. Biol. Chem. 281, 1680-1691
   Abstract »    Full Text »    PDF »
A Direct Synaptic Connection Mediating Both Excitation and Inhibition.
H. Wachtel and E. R. Kandel (1967)
Science 158, 1206-1208
   Abstract »    PDF »
Ionic Mechanisms of Cholinergic Excitation in Molluscan Neurons.
D. J. Chiarandini, E. Stefani, and H. M. Gerschenfeld (1967)
Science 156, 1597-1599
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)