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Science 23 June 1967:
Vol. 156. no. 3782, pp. 1595 - 1596
DOI: 10.1126/science.156.3782.1595
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Articles

Ionic Mechanism of Cholinergic inhibition in Molluscan Neurons

D. J. Chiarandini 1 and H. M. Gerschenfeld 1

1 Instituto de Anatomiacgra General ggr Embriologiacgra, Facultad de Ciencias Médicas, Buenos Aires, Argentina

Acetylcholine, the inhibitory transmitter to the so-called H-neurons of molluscs, produces its effect by increasing the permeability of the subsynaptic membrane to chloride ions. The change in permeability gives rise to a net influx of this anion, which hyperpolarizes the neuron. The presence of an outward pump of chloride ions is postulated to account for the required electrochemical gradient. The participation of potassium ions in this inhibitory phenomenon was not detected.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification and Functional Expression of a Family of Nicotinic Acetylcholine Receptor Subunits in the Central Nervous System of the Mollusc Lymnaea stagnalis.
P. van Nierop, S. Bertrand, D. W. Munno, Y. Gouwenberg, J. van Minnen, J. D. Spafford, N. I. Syed, D. Bertrand, and A. B. Smit (2006)
J. Biol. Chem. 281, 1680-1691
   Abstract »    Full Text »    PDF »
Active Transport of Potassium and Chloride in an Identifiable Molluscan Neuron.
J. M. Russell and A. M. Brown (1972)
Science 175, 1475-1477
   Abstract »    PDF »
Serotonin: Two Different Inhibitory Actions on Snail Neurons.
H. M. Gerschenfeld (1971)
Science 171, 1252-1254
   Abstract »    PDF »
A Direct Synaptic Connection Mediating Both Excitation and Inhibition.
H. Wachtel and E. R. Kandel (1967)
Science 158, 1206-1208
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)