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Science 16 June 1967:
Vol. 156. no. 3781, pp. 1514 - 1515
DOI: 10.1126/science.156.3781.1514
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Articles

Altered Response to Pneumococcal Polysaccharide in Offspring of Immunologically Paralyzed Mice

R. Kerman 1, D. Segre 1, and W. L. Myers 1

1 Department of Pathology and Hygiene, College of Veterinary Medicine, University of Illinois, Urbana

The dose of pneumococcal polysaccharide type III required to induce immunologic paralysis in newborn offspring of immunologically paralyzed mice was one-tenth of the corresponding paralyzing dose for newborn offspring of normal mice. Similarly, immunization of the offsprinig of the paralyzed mice was accomplished with one-tenth the dose of polysaccharide necessary to immunize normal newborn mice. The altered susceptibility of newborn mice from paralyzed mothers to the induction of both paralysis and immunity was predicted from theories of antibody formation which postulate that the induction of tolerance or immunity is controlled by the concentration of natural antibodies specific for the antigen used.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Summary: Waiting for the End.
N. Kaj Jerne (1967)
Cold Spring Harb Symp Quant Biol 32, 591-603
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Science. ISSN 0036-8075 (print), 1095-9203 (online)