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Science 9 June 1967:
Vol. 156. no. 3780, pp. 1367 - 1368
DOI: 10.1126/science.156.3780.1367
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Articles

Renal Erythropoietic Factor: Role of Ions and Vasoactive Agents in Erythropoietin Formation

Esmail D. Zanjani 1, Joseph F. Contrera 1, George W. Cooper 1, Albert S. Gordon 1, and Keith K. Wong 1

1 Laboratory of Experimental Hematology, Department of Biology, Graduate School of Arts and Science, New York University, New York

Evidence is provided for the existence of a renal erythropoietic factor, devoid of vasopressor activity, which upon interaction in vitro with normal serum yields erythropoietin. When undialyzed serum is used, erythropoietin inactivation develops in the incubation mixtures, and this inactivation appears to be dependent on an enzymatic component in preparations of the factor and on ions in serum.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)