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Science 2 June 1967:
Vol. 156. no. 3779, pp. 1257 - 1260
DOI: 10.1126/science.156.3779.1257
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Articles

Regulation of Intracellular Sodium Concentrations in Rat Diaphragm Muscle

Harry A. Fozzard 1 and David M. Kipnis 2

1 Department of Medicine, University of Chicago, Chicago, Illinois 60637
2 Department of Medicine, Washington University Medical School, St. Louis, Missouri

The concept is suggested that the sodium pump mechanism is influenced by the transmembrane electrical potential, and that the pump acts to maintain a constant electrochemical gradient for sodium. Evidence leading to this suggestion was obtained in rat diaphragm muscle by altering systematically the transmembrane chemical gradient for sodium ions and the transmembrane voltage. The voltage changes were produced by varying the extracellular and intracellular potassium ion concentrations. In each case the intracellular sodium concentration changed, presumably by activity of the sodium pump, so that the total electrochemical gradient for sodium was restored.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Familial Hypokalemic Periodic Paralysis: Local Recovery After Nerve Stimulation.
J. F. Campa and D. B. Sanders (1974)
Arch Neurol 31, 110-115
   Abstract »    PDF »
Hyperkalemic Periodic Paralysis: Intracellular Electromyographic Studies.
J. E. Brooks (1969)
Arch Neurol 20, 13-18
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)