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Science 2 June 1967:
Vol. 156. no. 3779, pp. 1237 - 1240
DOI: 10.1126/science.156.3779.1237
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Articles

Pyrimidine Nucleotide Synthesis: Regulatory Control during Transformation of Lymphocytes in vitro

Zoltan J. Lucas 1

1 Departmnents of Surgery and Biochemistry, Duke University Medical School, Durham, North Carolina

The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Abnormalities in Uridine Homeostatic Regulation and Pyrimidine Nucleotide Metabolism as a Consequence of the Deletion of the Uridine Phosphorylase Gene.
D. Cao, J. J. Leffert, J. McCabe, B. Kim, and G. Pizzorno (2005)
J. Biol. Chem. 280, 21169-21175
   Abstract »    Full Text »    PDF »
Uridylate Kinase Activity: Effect of Isoproterenol.
D. Malamud and R. Baserga (1968)
Science 162, 373-374
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)