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Science 26 May 1967:
Vol. 156. no. 3778, pp. 1102 - 1103
DOI: 10.1126/science.156.3778.1102
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Articles

Limited Heterogeneity of Gamma Globulin in Hypogammaglobulinemia

Richard Hong 1 and Robert A. Good 1

1 Variety Club Heart Hospital, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis 55455

When serums of 11 patients with hypogammaglobulinemia were examined by acrylamide-gel electrophoresis, combined with diffusion analysis, for the gamma chain of immunoglobulin G, the electrophoretic distribution of immunoglobulin G differed from that of normal individuals. The differences consisted of limited heterogeneity and bimodal distributions of the proteins at times. Isolated immunoglobulin G from four of the patients showed similar phenomena. The findings indicate a deficient gene population in these patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Deficient Complement Fixation by Aggregated Gamma Globulin from Hypogammaglobulinemic Patients.
R. J. Pickering, R. Hong, and R. A. Good (1967)
Science 157, 454-455
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Science. ISSN 0036-8075 (print), 1095-9203 (online)