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Science 19 May 1967:
Vol. 156. no. 3777, pp. 966 - 967
DOI: 10.1126/science.156.3777.966
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Articles

Penetration of an Organophosphorous Compound into Squid Axon and Its Effects on Metabolism and Function

F. C. G. Hoskin 1 and Philip Rosenberg 1

1 Departments of Biochemistry and Neurology, College of Physicians anid Surgeons, Columbia University, New York

The tertiary analogute of phospholine, namely, (C2H5O)2P(O)SCH2CH2N(CH3)2, is a potent, irreversible inhibitor of cholinesterase which, when externally applied to the sqluid giant axon, readily penetrates in its inhibitory form into the axoplasm. However, even a 10-2 molar solution of this compound does not block axonal conduction unless the axon is first treated with a low concentration of venom from the cottonmouth moccasin. The question of the activity of acetylcholinesterase in these axons is considered, and the possibility of subcellular permeability barriers for indivisual components of the excitable membrane is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diisopropylphosphorofluoridate and Tabun: Enzymatic Hydrolysis and Nerve Function.
F. C. G. Hoskin (1971)
Science 172, 1243-1245
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Science. ISSN 0036-8075 (print), 1095-9203 (online)