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Science 19 May 1967:
Vol. 156. no. 3777, pp. 947 - 948
DOI: 10.1126/science.156.3777.947
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Articles

Two Types Of Lambda Polypeptide Chains In Human Immunoglobulins

Daniel Ein 1 and John L. Fahey 1

1 National Cancer Institute, Bethesda, Maryland 20014

Two antigenic subtypes of human lambda polypeptide chains were distinguished by rabbit antiserum produced to a lambda Bence Jones protein. Lambda Bence Jones proteins and G myeloma proteins with lambda light chains were identified as being in one or the other subtype. The Oz (+) lambda chain subtype is present in light chains from pooled normal human immunoglobulin G and in whole normal immunoglobulin G molecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanism of Antibody Diversity: Germ Line Basis for Variability.
L. Hood and D. W. Talmage (1970)
Science 168, 325-334
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Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression.
A. G. Steinberg and I. Rostenberg (1969)
Science 164, 1072-1073
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The Structure of Immunoglobulin Light Chains.
E. Appella and R. N. Perham (1967)
Cold Spring Harb Symp Quant Biol 32, 37-44
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Science. ISSN 0036-8075 (print), 1095-9203 (online)