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Science 19 May 1967:
Vol. 156. no. 3777, pp. 945 - 946
DOI: 10.1126/science.156.3777.945
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Articles

Hormone-Dependent Differentiation of Mammary Gland: Sequence of Action of Hormones in Relation to Cell Cycle

Dean H. Lockwood 1, Frank E. Stockdale 1, and Yale J. Topper 1

1 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland

Differentiation of mouse mammary gland in vitro requires insulin, hydrocortisone, and prolactin. The epithelial cells must first divide in order to synthesize casein in response to these hormones. Insulin is required for the initiation of DNA synthesis and is also necessary during G1 phase (after mitosis). Prolactin can elicit the overt differentiative responses after mitosis. Activity of hydrocortisone precedes that of prolactin, that is, after mitosis it is not capable of eliciting the differentiative response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mammary Alveolar Epithelial Cells: Effect of Hydrocortisone on Ultrastructure.
E. S. Mills and Y. J. Topper (1969)
Science 165, 1127-1128
   Abstract »    PDF »
Hormone-Dependent Differentiation of Immature Mouse Mammary Gland in vitro.
A. E. Voytovich and Y. J. Topper (1967)
Science 158, 1326-1327
   Abstract »    PDF »


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