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Science 5 May 1967:
Vol. 156. no. 3775, pp. 667 - 669
DOI: 10.1126/science.156.3775.667
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Articles

Steroid-Sensitive Single Neurons in Rat Hypothalamus and Midbrain: Identification by Microelectrophoresis

K. Ruf 1 and F. A. Steiner 1

1 Department of Experimental Medicine, F. Hoffman-La Roche & Co. Ltd., Basel, and Institute for Brain Researchi, University of Zurich, Zutrich, Switzerland

Minute amounts of Na-dexamethasone-21-phosphate administered by microelectrophoresis to the immediate extracellular environment promptly suppressed electrical activity of 15 out of 115 hypothalamic and mesencephalic neurons, the effect being readily reversible. Such neurons marked with fast green were found to lie in circumscribed areas of the periventricular gray of the third ventricle and aqueduct, and may represent a site of action of adrenocortical steroids in the regulation of corticotrophin releasing factor and/or adrenocortico-tropin secretion by negative feedback.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuronal Correlates of Behavior in Freely Moving Rats.
B. R. Komisaruk and J. Olds (1968)
Science 161, 810-813
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