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Science 5 May 1967:
Vol. 156. no. 3775, pp. 646 - 648
DOI: 10.1126/science.156.3775.646
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Articles

Hexokinase Isoenzymes in Human Erythrocytes: Association of Type II with Fetal Hemoglobin

Edward W. Holmes Jr. 1, John I. Malone 1, Albert I. Winegrad 1, and Frank A. Oski 1

1 G. S. Cox Medical Research Institute, Department of Medicine, and Department of Pediatrics, University of Pennsylvania, Philadelphia 19104

Hexokinase activity in human erythrocytes is associated with three electrophoretically distinct bands. Normal adult erythrocytes contain hexokinases Types I and III. Type II hexokinase is present in the erythrocytes of newborn infants and absent from those of normal adults; it is, however, present in erythrocytes of adults with hereditary persistence of fetal hemoglobin. Type II hexokinase and fetal hemtoglobin appear to be associated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hemoglobin Receptor in Leishmania Is a Hexokinase Located in the Flagellar Pocket.
G. Krishnamurthy, R. Vikram, S. B. Singh, N. Patel, S. Agarwal, G. Mukhopadhyay, S. K. Basu, and A. Mukhopadhyay (2005)
J. Biol. Chem. 280, 5884-5891
   Abstract »    Full Text »    PDF »
Identification of the cDNA for Human Red Blood Cell-Specific Hexokinase Isozyme.
K. Murakami and S. Piomelli (1997)
Blood 89, 762-766
   Abstract »    Full Text »    PDF »
Hexokinase Isozymes in Human Erythrocytes.
G. J. Brewer, C. A. Knutsen, E. W. Holmes Jr., J. I. Malone, A. I. Winegrad, and F. A. Oski (1968)
Science 159, 650-651
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Hexokinase Isoenzymes in Human Erythrocytes.
J.-C. Kaplan and E. Beutler (1968)
Science 159, 215-216
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)