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Science 21 April 1967:
Vol. 156. no. 3773, pp. 402 - 403
DOI: 10.1126/science.156.3773.402
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Articles

Serotonin: Release in the Forebrain by Stimulation of Midbrain Raphé

George K. Aghajanian 1, John A. Rosecrans 1, and Michael H. Sheard 1

1 Department of Psychiatry, Yale University School of Medicine; Connecticut Mental Health Center, New Haven, Connecticut 06519

Electrical stimulation of the midbrain raphé, an area in which neuronal perikarya containing serotonin are aggregated, produces an increase in 5-hydroxyindoleacetic acid and a decrease in serotonin in the forebrain. These changes indicate that serotonin in the brain can be released via a specific neural pathway, namely, the system of axons projecting into the forebrain from serotonin-containing neurons in the midbrain raphé.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Persistent Increase in Brain Serotonin Turnover after Chronic Administration of LSD in the Rat.
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Histochemical Fluorescence of Raphe Neurons: Selective Enhancement by Tryptophan.
G. K. Aghajanian and I. M. Asher (1971)
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Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe.
G. K. Aghajanian, W. E. Foote, and M. H. Sheard (1968)
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Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD.
T. N. Chase, G. R. Breese, and I. J. Kopin (1967)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)