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Science 21 April 1967:
Vol. 156. no. 3773, pp. 392 - 394
DOI: 10.1126/science.156.3773.392
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Articles

Viral Hemorrhagic Encephalopathy of Rats

Adnan H. ElDadah 1, Neal Nathanson 1, Kendall O. Smith 2, Robert A. Squire 3, George W. Santos 3, and Edward C. Melby 3

1 Department of Epidemiology, Johns Hopkins University, School of Hygiene, Baltimore, Maryland 21205
2 National Institutes of Health, Bethesda, Maryland 20014
3 Departments of Pathology, Medicine, and Animal Medicine, Johns Hopkins University, School of Medicine, Baltimore 21205

A virus has been isolated and serially passed in suckling rats; it causes an acute fatal paralysis associated with hemorrhage and necrosis in the brain and spinal cord. The agent is relatively resistant to heat and ether, is about 20 millimicrons in diameter, and is antigenically closely related to rat virus. Its isolation resulted from the study of occasional cases of paralysis in adult rats after administration of cyclophosphamide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Persistent Rat Virus Infection in Smooth Muscle of Euthymic and Athymic Rats.
R. O. Jacoby, E. A. Johnson, F. X. Paturzo, and L. Ball-Goodrich (2000)
J. Virol. 74, 11841-11848
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)