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Science 14 April 1967:
Vol. 156. no. 3772, pp. 245 - 246
DOI: 10.1126/science.156.3772.245
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Articles

Thyroxine Interaction with Actinomycin D and Possible Biological Implications

Ki-Han Kim 1, Lois M. Blatt 1, and P. P. Cohen 1

1 Department of Physiological Chemistry, School of Medicine, University of Wisconsin, Madison 53706

Actinomycin D and thyroxine interact in solution (pH 8 to 10), as revealed by changes in the absorbance of actinomycin D. Thyroxine can prevent the growth-inhibitory effect of actinomycin D on Bacillus subtilis if it is present in a molar ratio of 3000 (thyroxine to actinomycin D).

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Science. ISSN 0036-8075 (print), 1095-9203 (online)