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Science 14 April 1967:
Vol. 156. no. 3772, pp. 243 - 245
DOI: 10.1126/science.156.3772.243
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Articles

Metachromatic Leukodystrophy (Sulfatide Lipidoses) Cultured in vitro

Humberto Cravioto 1, John O'Brien 1, Ruby Lockwood 1, Frederick H. Kasten 2, and Jon Booher 2

1 Departments of Pathology and Neurology, University of Southern California School of Medicine, Los Angeles 90033
2 Pasadena Foundation for Medical Research, Pasadena, California

Cerebral white matter from a patient with metachromatic leukodystrophly was successfully cultured in vitro. A luxuriant growth in Rose chambers and in roller tubes was apparent by the 14th day. The outgrown cells contained large numbers of granules which stained dark brown with cresyl violetacetic acid. The growth and metachromasia were maintained up to 80 days in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tay-Sachs Disease: Demonstration of the Stored Ganglioside in Cultured Cells From Brain Biopsy.
U. Batzdorf, L. L. Sarlieve, V. A. Gold, and J. H. Menkes (1969)
Arch Neurol 20, 650-652
   Abstract »    PDF »
The Sphingolipidoses and the Eye.
D. G. Cogan and T. Kuwabara (1968)
Arch Ophthalmol 79, 437-452
   Abstract »    PDF »
Metachromatic Leukodystrophy (MLD) VIII. MLD in Adults; Diagnosis and Pathogenesis.
J. Austin, D. Armstrong, S. Fouch, C. Mitchell, D. Stumpf, L. Shearer, and O. Briner (1968)
Arch Neurol 18, 225-240
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)