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Science 7 April 1967:
Vol. 156. no. 3771, pp. 100 - 102
DOI: 10.1126/science.156.3771.100
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Articles

Circadian Periodicity in Susceptibility to Lidocaine Hydrochloride

Edward F. Lutsch 1 and Ralph W. Morris 1

1 Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois, Chicago

Separate groups of mice standardized in an alternating 12-hour-light,12-hour-dark regimen were treated with lidocaine hydrochloride every 3 hours over a 24-hour period. The results indicate a quantitative circadian periodicity with maximal convulsant activity at 2100 hours which was approximately a fourteen fold increase over the values observed at 1500 hours.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronobiologic Considerations in Pharmacologic and Toxicologic Studies: Fact or Fancy.
V. Nair and A. Chedid (1983)
International Journal of Toxicology 2, 337-345
   Abstract »    PDF »
Diurnal Rhythm of Sensitivity of Cotton Seedlings to Herbicides.
J. G. Gosselink and L. C. Standifer (1967)
Science 158, 120-121
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)