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Science 31 March 1967:
Vol. 155. no. 3770, pp. 1685 - 1687
DOI: 10.1126/science.155.3770.1685
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Articles

Flaxedil (Gallamine Triethiodide): Evidence for a Central Action

Lawrence M. Halpern 1 and Richard G. Black 1

1 Departments of Pharmacology and Neurological Surgery, University of Washington School of Medicine, Seattle 98105

A central action of gallamine triethiodide has been demonstrated in cats with permanently implanted electrodes that permit direct repetitive stimulation and recording of afterdischarges from cerebral cortex. Systemically administered gallamine produced a consistent and reproducible augmentation of duration of afterdischarge at doses just sufficient to produce skeletal muscle paralysis. Simultaneous examination of expiratory carbon dioxide, blood pressure, body temperature, blood glucose, and direct cortical response to brief single stimuli failed to reveal any consistent peripheral change to which the centrally observed effecte Could be attributed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gallamine triethiodide (flaxedil): tetraethylammonium- and pancuronium-like effects in myelinated nerve fibers.
K. Smith and C. Schauf (1981)
Science 212, 1170-1172
   Abstract »    PDF »
Dopamine auto- and postsynaptic receptors: possible interference by gallamine.
L Garcia-Bunuel (1980)
Science 209, 720-721
   PDF »
Elevation of Lidocaine Seizure Threshold by Gallamine: In Rhesus Monkeys.
E. S. Munson and I. H. Wagman (1973)
Arch Neurol 28, 329-333
   Abstract »    PDF »
Gallamine (Flaxedil) and Synaptic Transmission in the Spinal Cord.
R. H. de Jong, R. Robles, and K.-I. Morikawa (1968)
Science 160, 768-769
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)