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Science 24 March 1967:
Vol. 155. no. 3769, pp. 1569 - 1571
DOI: 10.1126/science.155.3769.1569
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Articles

Acetyicholine Receptor: Similarity in Axons and Junctions

Philip Rosenberg 1 and Henry G. Mautner 2

1 Department of Neurology, Columbia University College of Physicians and Surgeons, New York
2 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Sulfur and selenium iso logs of benzoylcholine and its tertiary analog differ greatly in their abilities to block the electrical activity of squid axons. Presumably, differences in the biological activities of these compounds can be correlated with differences in their electron distribution. The relative effects on axons parallel those on junc tions of the electroplax, suggesting the presence of similar receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Local anesthetics: significance of hydrogen bonding in mechanism of action..
M. Sax and J. Pletcher (1969)
Science 166, 1546-1548
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Science. ISSN 0036-8075 (print), 1095-9203 (online)