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Science 17 March 1967:
Vol. 155. no. 3768, pp. 1432 - 1434
DOI: 10.1126/science.155.3768.1432
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Articles

Autologous Immune-Complex Pathogenesis of Experimental Allergic Glomerulonephritis

Thomas S. Edgington 1, Richard J. Glassock 1, and Frank J. Dixon 1

1 Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California

A renal tubular epithelial antigen is deposited in association with gamma globulin and complement in glomeruli from rats with experimental allergic glomerulonephritis induced by immunization with renal tubular antigens. Apparently, in normal kidneys this antigen is concentrated in the distal segment of the proximal convoluted tubular epithelium, and the principal source of this antigen in the glomerular deposits is autologous. This form of glomerulonephritis provides an experimental prototype for what may be termed "autologous immunecomplex" diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
T Cell Epitope Mimicry in Antiglomerular Basement Membrane Disease.
J. Arends, J. Wu, J. Borillo, L. Troung, C. Zhou, N. Vigneswaran, and Y.-H. Lou (2006)
J. Immunol. 176, 1252-1258
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A Self T Cell Epitope Induces Autoantibody Response: Mechanism for Production of Antibodies to Diverse Glomerular Basement Membrane Antigens.
J. Wu, J. Arends, J. Borillo, C. Zhou, J. Merszei, J. McMahon, and Y.-H. Lou (2004)
J. Immunol. 172, 4567-4574
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Conformation and Glycosylation of a Megalin Fragment Correlate with Nephritogenicity in Heymann Nephritis.
A. Tramontano and S. P. Makker (2004)
J. Immunol. 172, 2367-2373
   Abstract »    Full Text »    PDF »
A Small N-Terminal 60-kD Fragment of gp600 (Megalin), the Major Autoantigen of Active Heymann Nephritis, Can Induce a Full-Blown Disease.
A. V. OLEINIKOV, B. J. FELIZ, and S. P. MAKKER (2000)
J. Am. Soc. Nephrol. 11, 57-64
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Renal Vein Thrombosis and Nephrotic Syndrome: A Prospective Study of 36 Adult Patients.
F. LLACH, A. I. ARIEFF, and S. G. MASSRY (1975)
Ann Intern Med 83, 8-14
   Abstract »    PDF »
Autoimmunity: Present Concepts.
C. R. STILLER, A. S. RUSSELL, and J. B. DOSSETOR (1975)
Ann Intern Med 82, 405-410
   Abstract »    PDF »
Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
   Abstract »    PDF »
Membranous Glomerulonephritis: Evolution of Clinical and Pathologic Features.
M. C. GLUCK, G. GALLO, L. JEROME, and D. S. BALDWIN (1973)
Ann Intern Med 78, 1-12
   Abstract »    PDF »


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