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Science 17 March 1967:
Vol. 155. no. 3768, pp. 1426 - 1428
DOI: 10.1126/science.155.3768.1426
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Articles

Lysine Transport in Human Kidney: Evidence for Two Systems

Leon E. Rosenberg 1, Isidora Albrecht 1, and Stanton Segal 2

1 Yale University School of Medicine, New Haven, Connecticut
2 University of Pennsylvania School of Medicine and Philadelphia Children's Hospital, Philadelphia

Experiments with slices of human kidney cortex from two control subjects demonstrated two distinct transport systems for lysine (alpha and beta) which differ greatly in affinity and capacity. Both systems were found in kidney from two patients with cystinuria. Studies with rat kidney confirmed these findings. These experiments defined only a single transport system for cystine in kidney from both control and cystinuric subjects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia.
S. Broer (2008)
Physiol Rev 88, 249-286
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On the Enzymology of Amino Acid Transport.
A. Meister (1973)
Science 180, 33-39
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Use of Human Genetic Variation to Study Membrane Transport of Amino Acids in Kidney.
C. R. Scriver (1969)
Arch Pediatr Adolesc Med 117, 4-12
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Amino Acid Transport: Evidence for Genetic Control of Two Types in Human Kidney.
C. R. Scriver and O. H. Wilson (1967)
Science 155, 1428-1430
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