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Science 10 March 1967:
Vol. 155. no. 3767, pp. 1263 - 1266
DOI: 10.1126/science.155.3767.1263
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Articles

Crayfish Muscle: Permeability to Sodium Induced by Calcium Depletion

John P. Reuben 1, Philip W. Brandt 1, Lucien Girardier 1, and Harry Grundfest 1

1 Departments of Neurology and Anatomy, College of Physicians and Surgeons, Columbia University, New York; Institut de Physiologie, Université de Genève, Switzerland; and Marine Biological Laboratory, Woods Hole, Massachusetts

Membrane of crayfish muscle fibers becomes selectively permeable to sodium when the calcium concentration of the bathing medium is reduced. Removal of calcium or its reduction below 1 or 2 millimole per liter causes large transient depolarizations up to 70 millivolts in amplitude. They resemble pro longed action potentials and occur only in the presence of sodium. The responses are abolished when tris(hydroxymethyl)aminomethane or lithium is substituted for sodium, and are blocked by tetrodotoxin even in the presence of sodium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Covalent labeling of the tetrodotoxin receptor in excitable membranes.
R. Guillory, M. Rayner, and J. D'Arrigo (1977)
Science 196, 883-885
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Science. ISSN 0036-8075 (print), 1095-9203 (online)