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Science 3 March 1967:
Vol. 155. no. 3766, pp. 1118 - 1120
DOI: 10.1126/science.155.3766.1118
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Articles

Purified Staphylococcal Alpha Toxin: Effect on Epithelial Ion Transport

James J. Rahal Jr. 1, Martin E. Plaut 1, Herman Rosen 1, and Louis Weinstein 1

1 Infectious Disease Service and Renal Service, New England Medical Center Hospitals, and Tufts University School of Medicine, Boston, Massachusetts 02111

Purified staphylococcal alpha toxin, when added to the serosal bathing medium of the isolated toad bladder, causes a rapid fall in short-circuit current and transepithelial potential difference. It has no effect when added to the mucosal bathing medium. Oxygen consumption by suspensions of minced bladder tissue is stimulated by the toxin. These effects are neutralized by staphylococcal antitoxin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thrombocytopenia and Symmetrical Peripheral Gangrene Associated with Staphylococcal and Streptococcal Bacteremia.
J. J. RAHAL JR., H. E. MACMAHON, and L. WEINSTEIN (1968)
Ann Intern Med 69, 35-43
   Abstract »    PDF »
Ion Transport and Bacterial Toxins.
H. T. NORRIS (1967)
Ann Intern Med 67, 216-217
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)