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Science 3 March 1967:
Vol. 155. no. 3766, pp. 1106 - 1108
DOI: 10.1126/science.155.3766.1106
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Articles

Retinal Ganglion Cells: Specification of Central Connections in Larval Xenopus laevis

Marcus Jacobson 1

1 Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

In a series of Xenopus larvae (stages 28 to 35), the left eye cup was dorsoventrally and anteroposteriorly inverted. After metamorphosis, the retinotectal projection was mapped by recording action potentials evoked in the tectum by a small spot of light projected on the retina. Normal retinotectal projection was found following rotation of the eye cup at stage 28 to 29. Rotation of the eye cup at stage 30 resulted in anteroposterior inversion of the retinotectal projection; rotation at stages 31, 32, and 35 resulted in inversion of the projection in anteroposterior and dorsoventral axis of the retina. Therefore the retinal ganglion cells were unspecified at stage 28 to 29; spatial specification of ganglion cells occurred in the anteroposterior axis of the eye cup at stage 30 and in the dorsoventral axis between stages 30 and 31.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tbx5 and the Retinotectum Projection.
K. Koshiba-Takeuchi, J. K. Takeuchi, K. Matsumoto, T. Momose, K. Uno, V. Hoepker, K. Ogura, N. Takahashi, H. Nakamura, K. Yasuda, et al. (2000)
Science 287, 134-137
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Premature specification of the retina in embryonic Xenopus eyes treated with ionophore X537A.
M Jacobson (1976)
Science 191, 288-290
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Central projection of optic tract from translocated eyes in the leopard frog (Rana pipiens).
M Constantine-Paton and R. Caprianica (1975)
Science 189, 480-482
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Development of Specific Neuronal Connections.
M. Jacobson (1969)
Science 163, 543-547
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Science. ISSN 0036-8075 (print), 1095-9203 (online)