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Science 24 February 1967:
Vol. 155. no. 3765, pp. 1024 - 1026
DOI: 10.1126/science.155.3765.1024
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Photoinduced DNA-Protein Cross-Links and Bacterial Killing: A Correlation at Low Temperatures

Kendric C. Smith 1 and Mary E. O'Leary 1

1 Department of Radiology, Stanford University School of Medicine, Palo Alto, California 94304

The increased sensitivity of Escherichia coli to killing by ultraviolet irradiation when frozen and the variation in this sensitivity as a function of the temperature during irradiation have been correlated with changes in the amount of DNA that was cross-linked to protein by ultraviolet light. These variations in sensitivity to killing do not correlate with the production of thymine dimers.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)