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Science 17 February 1967:
Vol. 155. no. 3764, pp. 828 - 835
DOI: 10.1126/science.155.3764.828
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Articles

Evolution of Immunoglobulins: Structural Homology of Kappa and Lambda Bence Jones Proteins

Koiti Titani 1, Maurice Wikler 1, and Frank W. Putnam 1

1 Division of Biological Sciences, Indiana University, Bloomington

The amino acid sequence of a human lamba chain has been determined. There are many identities in sequence with human kappa chains, but this intraspecies homology is less than the interspecies homology of kappa light chains of man and mouse. Structural relationships suggest a common evolutionary origin and early differentiation of light- and heavy-chain genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunoglobulin Structure: Variability and Homology.
F. W. Putnam (1969)
Science 163, 633-643
   PDF »
Immunoglobulin Structure: Variation in Amino Acid Sequence and Length of Human Lambda Light Chains.
F. W. Putnam, T. Shinoda, K. Titani, and M. Wikler (1967)
Science 157, 1050-1053
   Abstract »    PDF »
Light Chains of Rabbit Immunoglobulin: Assignment to the Kappa Class.
R. F. Doolittle and K. H. Astrin (1967)
Science 156, 1755-1757
   Abstract »    PDF »
Structure and Evolution of Kappa and Lambda Light Chains.
F. W. Putnam, K. Titani, M. Wikler, and T. Shinoda (1967)
Cold Spring Harb Symp Quant Biol 32, 9-29
   Abstract »    PDF »
Common Peptides Comprising the N-terminal Half of Heavy Chain from Rabbit IgG and Specific Antibodies.
J. J. Cebra (1967)
Cold Spring Harb Symp Quant Biol 32, 65-73
   Abstract »    PDF »
Studies on Fragments of Light Chains of Human Immunoglobulins: Genetic and Biochemical Implications.
C. Baglioni, D. Cioli, G. Gorini, A. Ruffilli, and L. Alescio-Zonta (1967)
Cold Spring Harb Symp Quant Biol 32, 147-159
   Abstract »    PDF »
The Genetic Basis of Antibody Variability.
O. Smithies (1967)
Cold Spring Harb Symp Quant Biol 32, 161-168
   Abstract »    PDF »
The Genetic, Molecular, and Cellular Basis of Antibody Formation: Some Facts and a Unifying Hypothesis.
W. J. Dreyer, W. R. Gray, and L. Hood (1967)
Cold Spring Harb Symp Quant Biol 32, 353-367
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)