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Science 3 February 1967:
Vol. 155. no. 3762, pp. 582 - 585
DOI: 10.1126/science.155.3762.582
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Articles

Plasma Membrane: Substructural Changes Correlated with Electrical Resistance and Pinocytosis

Philip W. Brandt 1 and Alan R. Freeman 2

1 Departments of Anatomy and Neurology, Columbia University, New York 10032
2 Departments of Anatomy and Neurology, Columbia University, New York 10032; Department of Physiology, Rutgers Medical School, New Brunswick, New Jersey

Inducers of pinocytosis in amoeba cause as much as a 50-fold decrease in the electrical resistance of the plasma membrane prior to the formation of the typical tunnels and vacuoles. In this state the thickness of the electron-transparent core or lamella of the unit membrane is at least twice as thick as that of the control. The changes in structure and resistance as well as the induction of pinocytosis are dependent on the initial external concentration of calcium. These changes are rapidly reversed when the concentration of calcium in the external medium is increased.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)