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Science 3 February 1967:
Vol. 155. no. 3762, pp. 581 - 582
DOI: 10.1126/science.155.3762.581
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Articles

Contact Inhibition in Colony Formation

Harold W. Fisher 1 and Jen Yeh 1

1 Department of Bacteriology and Biophysics, University of Rhode Island, Kingston 02881

Contact inhibition of replication of the established mammalian cell line 3T3 was examined during growth of the colony and compared with that of the Chinese-hamster cell line CHL-1. The growth curves of cells in the colonies conformed to the predicted exponential and linear rates for CHL-1 and 3T3 respectively. Autoradiographs of colonies in which DNA was labeled with tritiated thymidine showed that in 3T3 colonies, only peripheral cells were labeled, while CHL-1 colonies were labeled throughout.


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Macrophage Nonimmunologic Recognition: Target Cell Factors Related to Contact Inhibition.
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