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Science 3 February 1967:
Vol. 155. no. 3762, pp. 539 - 541
DOI: 10.1126/science.155.3762.539
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Articles

Keto-Aldehydes and Cell Division

A. Szent-Györgyi 1, L. G. Együd 1, and Jane A. McLaughlin 1

1 Institute for Muscle Research, Marine Biological Laboratory, Woods Hole, Massachusetts

Many problems are left open in this article. Its publication may be excused by the suffering cancer causes, which urges the researcher to publish as soon as he thinks he may have found a new trail, which also may be taken by others. What emerges clearly is that SH groups, with their specific reactivities, offer a hopeful target in the search for cancerostatic substances, among which the natural repressor of cell division may hold out the most promise. The glyoxal derivatives also have antiviral properties (7, 16) and may be in the center of a hitherto unknown system of equilibria which deserves a thorough study. The low molecular weight of the glyoxal derivative reported justifies the hope of an early clarification of its structure, as well as its synthesis (17).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activity of the Yap1 Transcription Factor in Saccharomyces cerevisiae Is Modulated by Methylglyoxal, a Metabolite Derived from Glycolysis.
K. Maeta, S. Izawa, S. Okazaki, S. Kuge, and Y. Inoue (2004)
Mol. Cell. Biol. 24, 8753-8764
   Abstract »    Full Text »    PDF »
Identification of the Structural Gene for Glyoxalase I from Saccharomyces cerevisiae.
Y. Inoue and A. Kimura (1996)
J. Biol. Chem. 271, 25958-25965
   Abstract »    Full Text »    PDF »
Clinical Cancer Chemotherapy Aimed at Potential Cell Regulators.
F. E. Knock, R. M. Gait, O. V. Renaud, and Y. T. Oester (1970)
Arch Surg 100, 167-172
   Abstract »    PDF »
Cancer Chemotherapy Aimed At Potential Cell Regulators.
F. E. Knock, R. M. Galt, Y. T. Oester, and O. V. Renaud (1969)
JAMA 208, 534-535
   Abstract »    PDF »
Inhibitor of Bacterial Growth Released by Human Cells in Culture.
C. P. Kenny and B. G. Sparkes (1968)
Science 161, 1344-1345
   Abstract »    PDF »
Bioelectronics.
A. Szent-Gyorgyi (1968)
Science 161, 988-990
   PDF »
Cell Proliferation: Enhancement by Extracts from Cell Surfaces of Polyoma-Virus-Transformed Cells.
J. W. Beierle (1968)
Science 161, 798-799
   Abstract »    PDF »
Cancerostatic Action of Methylglyoxal.
L. G. Egyuud and A. Szent-Gyorgyi (1968)
Science 160, 1140
   PDF »
Protein-Sulfhydryl Groups In Cell Control Mechanisms.
F. E. Knock, R. M. Galt, and Y. T. Oester (1967)
JAMA 202, 550-551
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)