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Science 27 January 1967:
Vol. 155. no. 3761, pp. 482 - 484
DOI: 10.1126/science.155.3761.482
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Articles

Depression of Circulating Interferon Response in Balb/c Mice after Urethan Treatment

Jaqueline De Maeyer-Guignard 1 and Edward De Maeyer 1

1 Institut du Radium, 91, Orsay, France

Urethan, when given to female Balb/c mice, impaired the capacity of these animals to produce circulating interferon. The effect appeared rapidly after a single injection of either 1 or 1.5 milligrams of urethan per gram of body weight and was of short duration. The possibility that this inhibition of the production of interferon plays a role in the enhancement of viral leukemia by urethan should now be considered.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)