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Science 20 January 1967:
Vol. 155. no. 3760, pp. 350 - 352
DOI: 10.1126/science.155.3760.350
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Articles

Mechanism of Delayed Reactions

Sidney Leskowitz 1

1 Department of Bacteriology and Immunology, Harvard Medical School, and Department of Medicine, Massachusetts General Hospital, Boston

Arsanilic acid conjugates of polymers of L-typrosine, glutamic acid, and alanine are immunogenic and can elicit hapten-specific, delayed-hypersensitivity reactions in sensitized guinea pigs. Conjugates of the D-amino acid polymers are neither immunogenic nor capable of eliciting delayed reactions. Mixtures of small amounts of conjugates capable of eliciting a delayed reaction with larger amounts of D-amino acid polymer conjugates produce only small delayed reactions. I suggest that the delayed reaction is an active response requiring the continued participation of immunogenic material in sensitized animals; it is not the reaction of preformed antibody-like material with the antigenic determinant.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Summary: Waiting for the End.
N. Kaj Jerne (1967)
Cold Spring Harb Symp Quant Biol 32, 591-603
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Science. ISSN 0036-8075 (print), 1095-9203 (online)