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Science 20 January 1967:
Vol. 155. no. 3760, pp. 335 - 336
DOI: 10.1126/science.155.3760.335
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Articles

Iodide Transport: Inhibition by Agents Reacting at the Membrane

P. Reed Larsen 1 and J. Wolff 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Accumulation of iodide by thyroid tissue is inhibited by two phospholipase A-free proteins from cobra venom, filipin, crude phospholipase C, and lysolecithin. The venom proteins decrease K+ in tissue but do not significantly affect incorporation of phosphorus-32 into phospholipid or stimulation of this process by thyrotropin. However, filipin and crude phospholipase C, like thyrotropin, do increase phospholipid formation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)