Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 January 1967:
Vol. 155. no. 3760, pp. 329 - 330
DOI: 10.1126/science.155.3760.329
Prev | Table of Contents | Next

Articles

L-Asparaginase:Toxicity to Normal and Leukemic Human Lymphocytes

Robert Schrek 1, William C. Dolowy 2, and Robert N. Ammeraal 2

1 Tumor Research Laboratory, Veterans Administration Hospital, Hines, Illinois
2 Medical Research Laboratory, University of Illinois, Chicago

Quantitative in vitro tests showed that purified preparations of L-asparaginase from Escherichia coli were more toxic to blood lymphocytes from 12 of 15 patients with chronic lymphocytic leukemia than to lymphocytes from 25 persons with normal hemograms. Incubation for 7 days with 10 units per milliliter killed, on the average, 77 percent of leukemic and 34 percent of normal lymphocytes. The reagent produced appreciable toxicity to leukemic lymphocytes after 2 days of incubation.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)