Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 January 1967:
Vol. 155. no. 3759, pp. 217 - 219
DOI: 10.1126/science.155.3759.217
Prev | Table of Contents | Next

Articles

Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor

Walter Lovenberg 1, Eric Jequier 1, and Albert Sjoerdsma 1

1 Experimental Therapeutics Branch, National Heart Institute, Bethesda, Maryland

Development of a rapid and sensitive radioassay has permitted study of the conversion of tryptophan to 5-hydroxytryptophan in mammalian tissues. Of normal tissues examined, beef and rat pineal gland contained the highest activity. This is the first direct demonstration of tryptophan hydroxylase in this hydroxyindole-rich tissue. Rat and rabbit brainstem and human carcinoid tumor also had quantities of enzyme that could be measured easily. The reaction requires a reduced pteridine and oxygen and is inhibired by Para-Chorophenylalanine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice.
K. B. Neal, L. J. Parry, and J. C. Bornstein (2009)
J. Physiol. 587, 567-586
   Abstract »    Full Text »    PDF »
Daily Rhythm of Tryptophan Hydroxylase-2 Messenger Ribonucleic Acid within Raphe Neurons Is Induced by Corticoid Daily Surge and Modulated by Enhanced Locomotor Activity.
Z. S. Malek, D. Sage, P. Pevet, and S. Raison (2007)
Endocrinology 148, 5165-5172
   Abstract »    Full Text »    PDF »
A typical N-terminal Extensions Confer Novel Regulatory Properties on GTP Cyclohydrolase Isoforms in Drosophila melanogaster.
C. D. Funderburk, K. M. Bowling, D. Xu, Z. Huang, and J. M. O'Donnell (2006)
J. Biol. Chem. 281, 33302-33312
   Abstract »    Full Text »    PDF »
The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder.
R. Mossner, C. M. Freitag, L. Gutknecht, A. Reif, R. Tauber, P. Franke, J. Fritze, G. Wagner, G. Peikert, B. Wenda, et al. (2006)
J Psychopharmacol 20, 547-552
   Abstract »    PDF »
The Mechanism of Potent GTP Cyclohydrolase I Inhibition by 2,4-Diamino-6-hydroxypyrimidine: REQUIREMENT OF THE GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN.
M. A. Kolinsky and S. S. Gross (2004)
J. Biol. Chem. 279, 40677-40682
   Abstract »    Full Text »    PDF »
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.
F. Cote, E. Thevenot, C. Fligny, Y. Fromes, M. Darmon, M.-A. Ripoche, E. Bayard, N. Hanoun, F. Saurini, P. Lechat, et al. (2003)
PNAS 100, 13525-13530
   Abstract »    Full Text »    PDF »
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters.
V. Simonneaux and C. Ribelayga (2003)
Pharmacol. Rev. 55, 325-395
   Abstract »    Full Text »    PDF »
Photoneural Regulation of Rat Pineal Hydroxyindole-O-Methyltransferase (HIOMT) Messenger Ribonucleic Acid Expression: An Analysis of Its Complex Relationship with HIOMT Activity.
C. Ribelayga, F. Gauer, C. Calgari, P. Pevet, and V. Simonneaux (1999)
Endocrinology 140, 1375-1384
   Abstract »    Full Text »
Interaction of Phosphorylated Tryptophan Hydroxylase with 14-3-3 Proteins.
U. Banik, G.-A. Wang, P. D. Wagner, and S. Kaufman (1997)
J. Biol. Chem. 272, 26219-26225
   Abstract »    Full Text »    PDF »
Characterization of Mouse and Human GTP Cyclohydrolase I Genes.
H. Ichinose, T. Ohye, Y. Matsuda, T.-a. Hori, N. Blau, A. Burlina, B. Rouse, R. Matalon, K. Fujita, and T. Nagatsu (1995)
J. Biol. Chem. 270, 10062-10071
   Abstract »    Full Text »    PDF »
Characterization of the Human Tryptophan Hydroxylase Gene Promoter.
S. Boularand, M.čl. C. Darmon, P. Ravassard, and J. Mallet (1995)
J. Biol. Chem. 270, 3757-3764
   Abstract »    Full Text »    PDF »
Cerebrospinal Fluid Biopterin Is Decreased in Alzheimer's Disease.
A. D. Kay, S. Milstien, S. Kaufman, H. Creasey, J. V. Haxby, N. R. Cutler, and S. I. Rapoport (1986)
Arch Neurol 43, 996-999
   Abstract »    PDF »
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
S. Koslow and I. Butler (1977)
Science 198, 522-523
   Abstract »    PDF »
The Pineal Gland: A Neurochemical Transducer.
J. Axelrod (1974)
Science 184, 1341-1348
   PDF »
Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase.
D. C. Klein and J. L. Weller (1970)
Science 169, 1093-1095
   Abstract »    PDF »
Tetrahydrobiopterin Enhances Apoptotic PC12 Cell Death following Withdrawal of Trophic Support.
P. Z. Anastasiadis, H. Jiang, L. Bezin, D. M. Kuhn, and R. A. Levine (2001)
J. Biol. Chem. 276, 9050-9058
   Abstract »    Full Text »    PDF »
Catecholamines and Serotonin Are Differently Regulated by Tetrahydrobiopterin. A STUDY FROM 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE KNOCKOUT MICE.
C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, Y. Hagino, T. Nagatsu, T. Nomura, et al. (2001)
J. Biol. Chem. 276, 41150-41160
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)