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Science 13 January 1967:
Vol. 155. no. 3759, pp. 207 - 208
DOI: 10.1126/science.155.3759.207
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Articles

Psilocybin: Reaction with a Fraction of Rat Brain

L. P. Gilmour 1 and R. D. O'Brien 1

1 Section of Neurobiology and Behavior, Division of Biological Sciences, Cornell University, Ithaca, New York

Psilocybin, a hallucinogen, formed a blue color with a subfraction of rat-brain mitochondria believed to contain nerve-ending particles. Color formation increased with pH, did not require oxygen, and involved a component that could not be solubilized. The effect was not shown by chemically related neuroactive compounds, such as bufotenine and serotonin, and was antagonized by only tyramine or ethylenediaminetetraacetic acid.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)