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Science 13 January 1967:
Vol. 155. no. 3759, pp. 198 - 200
DOI: 10.1126/science.155.3759.198
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Articles

Tyrosinase Inhibition: Its Role in Suntanning and in Albinism

Lucia T. Y. Chian 1 and George F. Wilgram 1

1 Department of Dermatology, Harvard Medical School, Boston, Massachusetts

Tyrosinase inhibitor (molecular weight less than 5000; extracted from various melanomas) fully inhibits soluble tyrosinase but only partially inhibits tyrosinase "aggregated" into melanosomes; the inhibitor can be inactivated by ultraviolet light. S91 Albinotyrosinase Type B apparently cannot "aggregate" into melanosomes because its protein carrier is genetically altered. Therefore, albinotyrosinase remains vulnerable to its inhibitor and cannot produce melanin, even though the enzyme has a functioning active center.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Familial Progressive Hyperpigmentation.
M. E. Chernosky, D. E. Anderson, J. P. Chang, M. W. Shaw, and M. M. Romsdahl (1971)
Arch Dermatol 103, 581-598
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